Hyperpigmentation
Hyperpigmentation is a complex skin condition, often a result of sun exposure, hormonal shifts, or post-inflammatory marks. Our epigenetic formulations are designed to help even skin tone and reduce the appearance of dark spots by working with the skin’s biology, supporting barrier health while brightening without irritation or bleaching.
Product recommendations
Hyperpigmentation during pregnancy, perimenopause and in between.
The older the dark spots, the harder they are to be removed. But the Regulation Serum will attenuate the strength of the dark spots.
Apply Regulation Serum on the affected areas, 2x a day, morning and night.
Add a minimum skin care with 2 products, the Essential Duo.
Add a minimum skin care with 3 products, the Essential Trio.
Add a complete skin care with 4 products, our Foundational System, the Quartet.
Post inflammation hyperpigmentation (post acne)
For spots, Regulation Serum to be applied on the affected areas, 2x a day, morning and night.
For a minimum skincare with 2 products, add the Essential Duo.
Hyperpigmentation post summer sun
Apply the Regulation Serum on the affected areas, 2x a day, morning and night, followed by our Vitamin C Serum-in-oil on the whole face. A 3rd product that regulates the melanin production is our Exosome Advanced night Cream.
Why most hyperpigmentation solutions fail daily skin use
Hyperpigmentation is one of the most searched skincare concerns - and for good reason. From sunspots to post-acne marks, uneven skin tone tells a deeper biological story. But not all solutions are equal, and some may even harm more than help. Here’s what the science says, and how Skin Diligent’s Regulation Serum is designed to work with your skin, not against it.
Skincare ingredients unfit for skin health
- Hydroquinone: A strong melanin inhibitor. Effective short-term but associated with skin irritation, rebound pigmentation, and even ochronosis (a type of skin darkening). Banned in EU cosmetics.
- Kojic acid: It blocks tyrosinase but is unstable and can cause sensitisation with repeated use.
- Arbutin: A more gentle derivative of hydroquinone. Less toxic but also less potent, and still under regulatory watch.
- Tranexamic acid: Medically used to control bleeding, now used topically for melasma. But long-term topical safety remains under review, especially on thin skin.
Liver & hyperpigmentation link
The liver plays a central role in detoxification and hormone regulation. Several studies suggest that:
- Liver dysfunction or chronic congestion may impair the body’s ability to break down estrogens and inflammatory metabolites, both of which are known to exacerbate melasma and other types of pigmentation.
- A sluggish liver may indirectly increase systemic oxidative stress, which we now know to be a trigger for hyperpigmentation.
While hyperpigmentation itself does not signal liver disease, compromised liver detox function may contribute to the persistence of uneven skin tone in some individuals.